[Clinical Trial Design]          [Missing Data]           [Mediation Analysis]

Clinical Trial Design

Tang, R., Shen, J. and Yuan, Y. (2018) ComPAS: A Bayesian Drug-Combination Platform Design with Adaptive Shrinkage, Statistis in Medicine , to appear.

Lin R. and Yuan, Y. (2018) On the Relative Efficiency of Model-Assisted Designs: A Conditional Approach, Journal of Biopharmaceutical Statistics , to appear.

Mu, R.*, Yuan, Y. Xu, J. , Mandrekar, SJ., and Jun Y. (2018) gBOIN: A unified phase I trial design accounting for toxicity grades. Journal of the Royal Statistical Society: Series C , in press

Yan, F., Thall PF, Lu KH, Gilbert MR and Yuan, Y. (2018) Phase I-II clinical trial design: A state-of-the-art paradigm for dose finding. Annals of Oncology , 29, 694-699.

Zhou, H*, Murray, TA, Pan H and Yuan, Y. (2018) Comparative review of novel model-assisted designs for phase I clinical trials. Statistics in Medicine, 37, 2208-2222.

Yuan, Y., Lin, R., Li, D., Nie, L., and Warren K. (2018) Time-to-event Bayesian Optimal Interval Design to Accelerate Phase I Trials. Clinical Cancer Research, 24, 4921-4930.

Zhou, H.*, Yuan, Y. and Nie, L. (2018) Accuracy, Safety and Reliability of Novel Phase I Trial Designs. Clinical Cancer Research, 24, 4357-4364.

Guo, B., Li, D. and Yuan, Y. (2018) SPIRIT: A Seamless Phase I/II Randomized Design for Immunotherapy Trials. Pharmaceutical Statistics, 17, 527-540.

Chu, Y.* and Yuan, Y. (2018) BLAST: Bayesian Latent Subgroup Design for Basket Trials Accounting for Patient Heterogeneity. Journal of the Royal Statistical Society: Series C, 67, 723-740.

Chu, Y.* and Yuan, Y. (2018) A Bayesian Basket Trial Design Using Calibrated Bayesian Hierarchical Model. Clinical Trials, 15, 149-158.

Liu, S., Guo, B. and Yuan, Y. (2018) A Bayesian Phase I/II Design for Immunotherapy Trials. Journal of the American Statistical Association, 113, 1016-1027.

Riviere, M.K., Yuan, Y., Jourdan, J.H., Dubois, F. and Zohar, S. (2018) Phase I/II Dose-Finding Design for Molecularly Targeted Agent: Plateau Determination using Adaptive Randomization. Statistical Methods in Medical Research, 27, 466-479.

Murray, T.*, Yuan, Y., Thall, P., Elizondo, JH. and Hofstetter, WL. (2018) A Bayesian Utility-Based Stratified Medicine Design for the Effectiveness of Nutritional Prehabilitation in Thoracic Surgery. Biometrics, 74, 1095-1103.

Murray, T.*, Yuan, Y. and Thall, P. (2018) A Bayesian Machine Learning Method for Optimizing Dynamic Treatment Regimes. Journal of the American Statistical Association, 113, 1255-1267.

Yan, F., Mandrekar, SJ. and Yuan, Y. (2017) Keyboard: A Novel Bayesian Toxicity Probability Interval Design for Phase I Clinical Trials. Clinical Cancer Research, 23, 3994-4003.

Zhou, H.*, Lee, JJ. and Yuan, Y. (2017) BOP2: Bayesian Optimal Design for Phase II Clinical Trials with Simple and Complex Endpoints. Statistics in Medicine , 36, 3302-3314.

Pan, H.* and Yuan, Y. (2017) A Calibrated Power Prior Approach to Borrow Information from Historical Data with Application to Biosimilar Clinical Trials. Journal of the Royal Statistical Society: Series C , 66, 979-996.

Guo, B.* and Yuan, Y. (2017) Bayesian Phase I/II Biomarker-based Dose Finding for Precision Medicine with Molecularly Targeted Agents. Journal of the American Statistical Association, 112, 508-520.

Murray, T.*, Thall, P., Yuan, Y., McAvoy, S. and Gomez, D. (2017) Robust treatment comparison based on utilities of semi-competing risks in non-small-cell lung cancer. Journal of the American Statistical Association, 112, 11-23.

Zang, Y.* and Yuan, Y. (2017) Optimal Sequential Enrichment Designs for Phase II Clinical Trials. Statistics in Medicine, 36, 54-66.

Yuan, Y., Hess, K., Hilsenbeck, S. and Gilbert, M. (2016) Bayesian Optimal Interval Design: A Simple and Well-Performing Design for Phase I Oncology Trials. Clinical Cancer Research, 22, 4291-430.

Yuan, Y., Guo, B, Munsell, M., Lu, K. and Jazzari, A. (2016) MIDAS: a practical Bayesian design for platform trials with molecularly targeted agents. Statistics in Medicine, 35, 3892-3906.

Zang, Y.*, Liu, S. and Yuan, Y. (2016) Optimal Marker-strategy Clinical Trial Design to Detect Predictive Markers for Targeted Therapy. Biostatistics, 17, 549-560.

Zhang, L.* and Yuan, Y. (2016) A Practical Bayesian Design to Identify the Maximum Tolerated Dose Contour for Drug Combination Trials. Statistics in Medicine, 35, 4924-4936.

Riviere, M.K.*, Yuan, Y., Jourdan, J.H., Dubois, F. and Zohar, S. (2016) Phase I/II Dose-Finding Design for Molecularly Targeted Agent: Plateau Determination using Adaptive Randomization. Statistical Methods in Medical Research, to appear

Chu, Y.*, Pan, H. and Yuan, Y. (2016) Adaptive dose modification for phase I clinical trials. Statistics in Medicine, 35, 3497-508.

Iasonos, A. , Wages N., Conaway, M., Cheung, K., Yuan, Y. and O’Quigley, J. (2016) Dimension of Model Parameter Space and Operating Characteristics in Adaptive Dose-Finding Studies. Statistics in Medicine, 35, 3760-3775.

Pan, H.* and Yuan, Y. (2016) A Default Method to Specify Skeletons for Bayesian Model Averaging Continual Reassessment Method for Phase I Clinical Trials. Statistics in Medicine, 36, 266-279.

Zang, Y.*, J. Lee and Yuan, Y. (2016) Two-stage marker-stratified clinical trial design in the presence of biomarker misclassification. Journal of the Royal Statistical Society: Series C, 65, 585-601.

Guo, B., Li, Y. and Yuan, Y. (2016) A dose-schedule-finding design for phase I/II clinical trials. Journal of the Royal Statistical Society: Series C, 65, 259-272.

Chen, Z., Yuan, Y., Li, Z., Kutner, M., Owonikoko, T., Curran, W, Khuri, F. and Kowalski, J. (2015) Dose escalation with over-dose and under-dose controls in phase I/II clinical trials. Contemporary Clinical Trials, 43, 133-141.

Shen, W.*, Ning, J. and Yuan, Y. (2015) Bayesian sequential monitoring design for clinical trials with non-compliance Statistics in Medicine, 34, 2104-2115.

Zang, Y.*, Liu, S. and Yuan, Y. (2015) Optimal Marker-Adaptive Designs for Targeted Therapy Based on Imperfectly Measured Biomarkers. Journal of the Royal Statistical Society: Series C, 64, 635-650.

Liu, S. and Yuan, Y. (2015) Bayesian Optimal Interval Designs for Phase I Clinical Trials. Journal of the Royal Statistical Society: Series C, 64, 507-523.

Guo, B. and Yuan, Y. (2015) A Bayesian Design for Phase I/II Clinical Trials with Nonignorable Dropout. Statistics in Medicine, 34, 1721-1732.

Shen, W.*, Ning, J. and Yuan, Y. (2015) A Direct Method to Evaluate the Time-dependent Predictive Accuracy for Biomarkers. Biometrics, 71, 439-449.

Liu, S., Pan, H., Huang Q., Xia, J. and Yuan, Y. (2015) Bridging Continual Reassessment Method for Phase I Clinical Trials in Different Ethnic Populations. Statistics in Medicine, 10, 1681-1694.

Riviere, M.K.*, Yuan, Y., Dubois, F. and Zohar, S. (2015) A Bayesian Dose-finding Design for Clinical Trials Combining a Cytotoxic Agent with a Molecularly Targeted Agent. Journal of the Royal Statistical Society: Series C, 64, 215-229.

Jin, I.H.*, Liu, S., Thall, P. and Yuan, Y. (2014) Using Data Augmentation to Facilitate Conduct of Phase I/II Clinical Trials with Delayed Outcomes. Journal of the American Statistical Association, 109, 525-536.

Riviere M.K., Yuan Y. , Dubois F. and Zohar S. (2014) A Bayesian dose-finding design for drug combination clinical trials based on the logistic model. Pharmaceutial Statistics, 13, 247-257.

Zang, Y.*, Lee J. and Yuan, Y. (2014) Adaptive designs for identifying optimal biological dose for molecularly targeted agents. Clinical Trials, 11, 319-327.

Cai, C.*, Liu, S. and Yuan, Y. (2014) A Bayesian Design for Phase II Clinical Trials with Delayed Responses Based on Multiple Imputation. Statistics in Medicine, 33, 4017-4028.

Liu, S., Yuan, Y. , Castillo, R., Guerrero, T. and Johnson, V.E. (2014) Evaluation of Deformable Image Registration Spatial Accuracy Using a Bayesian Hierarchical Model. Biometrics, 70, 366-377.

Cai, C.*, Yuan, Y. and Ji, Y. (2014) A Bayesian Phase I/II Design for Oncology Clinical Trials of Combining Biological Agents. Journal of the Royal Statistical Society: Series C, 63, 159-173.

Liu, S., Yin, G. and Yuan, Y. (2013) Bayesian Data Augmentation Dose Finding with Continual Reassessment Method and Delayed Toxicity. Annals of Applied Statistics, 4, 2138-2156.

Ahn, J.*, Yuan, Y., Parmigiani, G., Suraokar, M. B., Diao, L., Wistuba, I. and Wang W. (2013) DeMix: Deconvolution for mixed cancer transcriptomes using raw measured data. Bioinformatics, 29, 1865-1871.

Cai, C.*, Yuan, Y. and Johnson, V.E. (2013) Bayesian adaptive phase II screening design for combination trials. Clinical Trials, 10, 353-362.

Jin, I.H.*, Yuan, Y. and Liang, F. (2013) Bayesian analysis for exponential random graph models using the adaptive exchange sampler. Statistics and Its Interface, 6, 559-576.

Zang, Y*. and Yuan, Y. (2013) A Shrinkage Method for Testing the Hardy-Weinberg Equilibrium in Case-Control Studies. Genetic Epidemiology, 37, 743-750.

Yuan, Y., Thall, P. andWolf, J. (2012) Estimating Progression-free Survival When the Progression Status of Some Subjects is Unknown. Journal of the Royal Statistical Society: Series C, 61, 135-149.

Yuan, Y. and Johnson, V.E. (2012) Goodness-of-Fit Diagnostics for Bayesian Hierarchical Models. Biometrics 68, 156-164.

Huo, L.*, Yuan, Y. and Yin, G. (2012) Dose Finding in Drug Combinations with Discrete and Continuous Doses. Bayesian Analysis, 7, 235-252.

Yuan, Y. and Yin, G. (2011) Robust EM Continual Reassessment Method in Oncology Dose Finding. Journal of the American Statistical Association 106, 818-831. (featured article)

Lei, X., Yuan, Y. and Yin, G. (2011) Bayesian phase II adaptive randomization by jointly modeling time-to-event efficacy and binary toxicity. Lifetime Data Analysis 17, 156-174.

Yuan, Y. and Yin, G. (2011) Bayesian phase I/II drug-combination trial design in oncology. Annals of Applied Statistics, 5, 924-942.

Yuan, Y. and Yin, G. (2011) Bayesian Hybrid Design in Phase I Oncology Clinical Trials. Statistics in Medicine, 30, 2098-2108.

Yuan, Y., Huang, X. and Liu, S. (2011) A Bayesian response-adaptive covariate-balanced randomization design for clinical trials. Statistics in Medicine, 30, 1218-1229.

Yuan, Y. and Yin, G. (2011) On adaptive randomization: is it useful? Journal of Clinical Oncology, 29, e390-e392

Yin, G., Ma, Y., Liang, F. and Yuan, Y. (2011) Stochastic generalized method of moments. Journal of Computational and Graphical Statistics 20, 714-727.

Yuan, Y. and Yin, G. (2011) Dose-response curve estimation: A semiparametric mixture approach. Biometrics 67, 1543-1554.

Yin, G. and Yuan, Y. (2009) Bayesian Model Averaging Continual Reassessment Method in Phase I Clinical Trials. Journal of the American Statistical Association 104, 954-968.

Song P.X., Li, M. and Yuan, Y. (2009) Joint Regression Analysis of Correlated Data Using Gaussian Copulas. Biometrics 65, 60-68.

Yin, G. and Yuan, Y. (2009) A latent contingency table approach to dose-finding for combinations of two agents. Biometrics 65, 866-875.

Yin, G. and Yuan, Y. (2009) Bayesian Dose-finding in Oncology for Drug Combinations by Copula Regression. Journal of the Royal Statistical Society: Series C 58, 211-224.

Yuan, Y. and Yin, G. (2009) Bayesian Dose-finding by Jointly Modeling Toxicity and Efficacy as Time-to-Event Outcomes. Journal of the Royal Statistical Society: Series C 58, 719-736.

Yuan, Y. and Johnson, V.E. (2008) Bayesian Hypothesis Tests Using Nonparametric Statistics. Statistica Sinica 18, 1185-1200

Yuan, Y. and Yin, G. (2008) Sequential Continual Reassessment Method for Two-dimensional Dose Finding. Statistics in Medicine 27, 5664-5678.

Missing Data Analysis

Ahn, J.*, Liu, S., Wang W. and Yuan, Y. (2013) Bayesian Latent-class Mixed-effect Hybrid Models for Dyadic Longitudinal Data with Non-ignorable Dropouts. Biometrics, 69, 914-924.

Zhang G. and Yuan, Y. (2012) Modeling Longitudinal Dyadic Data with Nonignorable Dropout with Application to a Breast Cancer Study. Annals of Applied Statistics, 6, 753-771.

Yuan, Y. and Yin, G. (2010). Quantile regression for longitudinal studies with nonignorable missing data. Biometrics, 66, 105-114.

Yuan, Y. and Little, R.J.A. (2009) Meta-analysis of studies with missing data. Biometrics 65, 487-496.

Yuan, Y. and Little, R.J.A. (2009) Mixed-effect hybrid models for longitudinal data with nonignorable dropout. Biometrics 65, 478-486.

Yuan, Y., and Little, R.J.A. (2007) Model-Based Estimates of the Finite Population Mean for Two-Stage Cluster Samples with Unit Non-response. Journal of the Royal Statistical Society: Series C 56, 79-97.

Yuan, Y., and Little, R.J.A. (2007) Parametric and Semiparametric Model-based Estimates of the Finite Population Mean for Two-Stage Cluster Samples with Item Nonresponse. Biometrics 63, 1172-1180.

Mediation Analysis

Huang J., Yuan, Y. and Wetter D. (2018) Latent Class Dynamic Mediation Model with Application to Smoking Cessation Data, Psychometrika, 22(4):667-686.

Huang, J.* and Yuan, Y. (2017) Bayesian Dynamic Mediation Analysis, Psychological Methods, to appear.

Yuan, Y. and MacKinnon D. (2014) Robust mediation analysis based on mediation regression. Psychological Methods, 19, 1-20.

Yuan, Y. and MacKinnon D. (2009) Bayesian mediation analysis. Psychological Methods, 14, 301-322.